By plane

• Southwest Florida International Airport (RSW IATA), 11000 Terminal Access Rd (16 mi (26 km) South of downtown via Exit 128 from I-75 on Terminal Access Rd), ☏ +1 239 590-4800. . Non-stop service is available from most major U.S. cities, intrastate flights from other parts of the state (Southwest Airlines from Orlando), and a few international flights from Canada (Air Canada and Westjet) with the following: 

• Concourse B: Air Canada, Alaska, Frontier, Southwest, Sun Country
• Concourse C: Delta/Delta Connection, United, WestJet
• Concourse D: American, JetBlue, Spirit

Onsite car rental is located in a separate 26.5273-81.75552 Car Rental Building across the street from the baggage reclaim doors (lower level). It is accessible by crossing the street from outside Doors 3 (Delta Airlines) or 4 at lower level. Bus stop for LeeTran Rt#50 (Airport to Sanibel Outlets) is located outside Door #2 (WestJet), on the island, across the road. Click here or inquire with the ‘Transportation Information’ booth outside of Door #3 at arrival for additional info regarding other shuttle/taxi (ground transport) services, hotel shuttles, off site rental car companies, and their pick up locations.

Miami International Airport (MIA IATA) and Ft Lauderdale (FLL IATA) are the next nearest airports for a wider range of domestic and international flights. From Miami International Airport, Greyhound offer direct bus service to downtown Ft Myers (5 hr) (see below under ‘By bus’) or rent a car and drive over along I-75 or US Hwy 41.

By bus

• Flixbus, (bus stop) Parking Lot 5 at Florida Gulf Coast University (Bus will board at Florida Gulf Coast University, curbside in front of McTarnaghan Hall, adjacent to Parking Lot Five.). Travels primarily on Interstate 75 (Miami, Ft Lauderdale, Naples, Ft Myers, Sarasota, Tampa). (updated Nov 2019)
• Greyhound Lines, (bus station) 2250 Widman Way (Rosa Parks Transportation Center on Widman between Jackson & Hendry St), ☏ +1 239 334-1011, toll-free: +1 800 231-2222. Travels primarily on Interstate 4/75 (Orlando, Tampa, St Petersburg, Sarasota, Port Charlotte, Ft Myers, Naples); SR-80/US98/I-95 (Ft Myers, Clewiston, Belle Glade, W Palm Beach, Ft Lauderdale, Miami). Passengers transfer in Orlando, West Palm Beach or Miami to reach additional destinations. Direct connections to LeeTran buses at the Rosa Parks Transportation Center, next to the Greyhound bus station, for onward local public transportation. (updated May 2021)
• Redcoach, (bus stop) 11090 FGCU Blvd N (bus stop near Cohen Center on FGCU Blvd N on the campus of the Florida Gulf Coast University (FGCU).), ☏ +1 407-851-2843, toll-free: +1-877-733-0724. Redcoach has one route that passes through Ft Lauderdale, Naples, Ft Myers and Tampa on its way between Miami Airport and Tallahassee. (updated Sep 2017)

By ferry

• Key West Express Ferries, 1200 Main St, Ft Myer Beach, ☏ +1 239 463-5733, toll-free: +1 888 539-2628. Daily passenger only ferries between Ft Myers Beach and Key West. Journey time takes 3.5 hours. (updated May 2021)

By train

• Amtrak Thruway Motorcoach (Operated by Martz First Class), (bus stop) 6050 Plaza Dr (Pilot Travel Center off of Exit #139 of I-75). The Amtrak Motorcoach bus operates as an extension of Amtrak’s Silver Star train from Tampa to Ft Myers via St Petersburg, Bradenton, Sarasota and Port Charlotte. (updated May 2021)

• The tropical climate is perfect for bicycling, and Fort Myers is a very bicycle friendly city. But watch out for those occasional pop up showers, especially during the wet season. When cycling, be sure to bring plenty of water, wear light weight, light colored clothing, and wear sunscreen.
• Lee trans is the local bus service and has numerous bus lines criss-crossing the city.
• The Midpoint and Cape Coral Pwky/Colonial Bridge is $2 going from Fort Myers to Cape Coral only. Other direction is non toll. The bridge is generally unavoidable unless you go through downtown Fort Myers and US41 around.

The Sanibel Causeway to Sanibel Island collapsed during the hurricane in 2022.

• Butterfly Estates, 1815 Fowler Street, ☏ +1 239 690-2359. 9AM – 5PM. This butterfly conservatory, set in the Fort Myers river district, is home to all the species of butterfly native to Florida. The enclosure features a cascading waterfall and many exotic species of plants. Every Friday at 1:30PM new butterflies are released into the exhibit, which makes this the best time to visit. $15. 
• Edison and Ford Winter Estates, 2350 McGregor Blvd, ☏ +1 239 334-7419. Every day 9AM-5:30PM (during Dec until 9PM). Guided tours through 15,000 sq. ft. museum with hundreds of Edison and Ford inventions and objects, video theatres, and changing special exhibits. Beautiful and interesting plantings on the grounds.  
• Minnesota Twins Spring Training, 14100 Six Mile Cypress Parkway, ☏ +1 612 338-9467. Hammond Stadium. If you are in Fort Myers during the spring, you may be able to see the Major Baseball League’s Minnesota Twins’ during their preseason training period. (2007 prices) Dugout Box, $35; Box Seats, $21; Reserved Seats, $19; Deck Rail, $15; Lawn Seating, $10; Standing Room, $10.  
• Boston Red Sox Spring Training, Fenway South Dr (JetBlue Park at Fenway South), ☏ +1 239 334-4700. The Boston Red Sox also have their spring training in Fort Myers. 
• Fort Myers Mighty Mussels (Hammond Stadium). Professional baseball in Fort Myers doesn’t stop with spring training—the Minnesota Twins have a minor-league affiliate based in their spring training complex. The Mighty Mussels, newly renamed from the Miracle, play in the Florida State League, an “Advanced A” league (three levels below Major League Baseball) mainly featuring younger players a year or two out of high school or college baseball.  
• Florida Gulf Coast Eagles (FGCU Eagles). Sports teams of Florida Gulf Coast University, competing in 15 NCAA Division I sports (6 men’s, 9 women’s) mainly in the ASUN Conference, featuring a mix of mostly regional universities in the southeastern quadrant of the country (as well as one outlier in New Jersey). With no football team, the most popular sports are men’s and women’s basketball. The mapped location is Alico Arena, home to both basketball teams, women’s volleyball, and the main athletic ticket office. 
• Florida Everblades. Local hockey.
• FGCU Eagles Hockey. A club-level ice hockey team that competes outside the NCAA structure (and thus is not part of the overall FGCU athletic program), but nonetheless a popular winter diversion. 
• Sanibel Lighthouse.  
• Calusa Nature Center and Planetarium, 3450 Ortiz Ave (at Colonial Blvd), ☏ +1 239 275-3435. (updated Jun 2020)
• Koreshan State Historic Site, 3800 Corkscrew Road, Estero, ☏ +1 239 992-0311. 8AM to sunset. Cyrus Teed, creator of the religion of ‘Koreshanity’ founded his ‘New Jerusalem’ community here. Various structures, many over a century old, are still preserved. (updated Feb 2015)
  • Mound Key Archaeological State Park, The park is accessible only by boat and is managed by Koreshan State Historic Site, Estero, ☏ +1 239 992-0311. 8AM to sunset.  

• Paint a coconut at one of the many art galleries on colourful pine island
• Head to Matanzas Pass Preserve on the 7-mile long island of Estero and into the 60-acre mangrove where crabs, lizards and birds live in abundance.
• Visit the Edison & Ford Winter Estates featuring 20 acres of tropical gardens and the largest banyan tree in the US.
• Make the most of Fort Myers’ Music Walk every third Friday of the month and hear the streets filled with live music.
• Sky Zone Fort Myers.  – located in Fort Myers.
• Good Time Charters and Tours, 4765 Estero Blvd Ft Myers Beach (behind the Publix by the Bayfront Bistro), ☏ +1 239-218-8014, tours@goodtimecharter.com. A dolphin cruise with them is excellent. They have biologists on board and are laid back and fun. Free parking on site. (updated Feb 2018)
• Paradise Charters LLC, 4765 Estero Blvd Fort Myers Beach (behind Publix by the Bayfront Bistro), ☏ +1 239-247-8288, cristina@paradisechartersllc.com. Friendly fishing charters. (updated Feb 2018)
• Lagerhead Cycleboats, 2500 Main Street, ☏ +1 239 312-3137, info@lagerheadcycleboats.com. (updated Jul 2018)
• Estero Bay Preserve State Park, The park is managed by Koreshan State Historic Site located at 3800 Corkscrew Road in Estero, ☏ +1 239 992-0311. 8AM to sunset.  
• Lovers Key State Park, 8700 Estero Blvd, Fort Myers Beach, ☏ +1 239 463-4588. 8AM to sunset.  

• The Shell Factory. 2787 North Tamiami Trail. The complex features jewelry, and collectibles made from sea shells, carved coconut souvenirs, T-shirts, tropical ladies wear, a pirate exhibit, wild animal display of over 66 different animals, a small live animal Nature park, restaurants, entertainment for children, the largest year-round Christmas holiday shop, and other attractions. One reason The Shell Factory is a popular source of collectible conch shells is that, under Florida Fish and Wildlife Conservation Commission (FWC) regulations, there is a restriction in Lee County for the collection of any sea shells along its beaches if there is a living organism inhabiting the shell, with the exception of oysters, hard clams, Sunray Venus clams and Coquinas. 

One of its most recent and significant activity developments at the Shell Factory is its schedule of Flea-Market days. Every Tuesday, Thursday and, Saturday from sunrise until the heat of the day drives them away, you will find local people as well as, residents from all across the state, setting up tables and tents on reserved parts of the parking lots. They offer their personal goods, many interesting pieces and often, rare collectible items for sale to the public.

• Miromar Factory Outlet Mall. 
• Gulf Coast Town Center.  
• Bell Tower. 
• Coconut Pointe Town Center. 
• Edison Mall, 4125 Cleveland Ave, ☏ +1 239-939-5464. (updated May 2021)
• Fleamasters Flea Market. 

• lakka Greek Restaurant
• Iguana Mia Mexican Restaurant. 
• Siam Hut, Cape Coral Pkwy and Del Prado. Thai.
• Ford’s Garage, 2207 First St. 11:00 – 11:00. (updated Feb 2018)

• The Cigar Bar, Downtown Fort Myers and Gulf Coast Town Mall
• Blu Sushi, Fort Myers and Gulf Coast Town Center (Estero)
• Anthonys Junkanoo, 3040 Estero Blvd. Nice beachclub with full bar. 

• Best Western Waterfront, 13021 N. Cleveland Avenue, ☏ +1 239 997-5511, toll-free: +1-800-274-5511. Right on the river. Private pier, high-speed internet and heated outdoor pool. 
• Cypress Trail RV Resort, 5468 Tice Street, Fort Myers, FL 33905, ☏ +1 239 333-3246. Luxury RV resort with aquatic center and recreation that includes two private lakes and paddleboats. (updated Oct 2018)
• DiamondHead Beach Resort, 2000 Estero Boulevard, toll-free: +1-888-627-1595. Fort Myers Beach. All suite luxury resort with conference facilities. Right on the beach. 
• GullWing Beach Resort, 6620 Estero Boulevard, ☏ +1 239 765-4300, toll-free: +1-888-627-1595. Suites and condos on Fort Myers beach as well as meeting and banquet space. 
• Howard Johnson Inn, 4811 s Cleveland Avenue. Old motel located in the center. 
• Hyatt Regency Coconut Point, 5001 Coconut Road (Bonita Springs), ☏ +1 239 444-1234, fax: +1 239 390-4344. 
• Lover’s Key Resort, 8771 Estero Boulevard, ☏ +1 239 765-1040, toll-free: +1-877-798-4879. All-suite resort adjacent to the Lover’s Key State Park with views of Estero Bay, lagoon-style pool, and on-site dining (updated Feb 2016)
• Pink Shell Beach Resort & Spa, 275 Estero Boulevard. On Estero Island. 
• Pointe Estero Beach Resort, 6640 Estero Boulevard, toll-free: +1-888-627-1595. A beachfront suite hotel located on the peaceful southern end of Estero Island. 
• Santa Maria Harbour Resort, 7317 Estero Boulevard, toll-free: +1-888-627-1595. A resort on Estero Bay, a fishing harbour on Estero Island. 
• Suburban Extended Stay Hotel of Fort Myers, 10150 Metro Parkway, ☏ +1 239 938-0100. Rooms have refrigerators, microwaves, coffee makers, utensils, irons, ironing boards, computer hook-ups, voice mail and satellite television. King suites are also available. 
• Sanibel Harbour Marriott Resort & Spa, 17260 Harbour Pointe Dr, ☏ +1 239-466-4000, toll-free: +1-800-767-7777. Check-in: 4:00 PM, check-out: 11:00 AM. Oceanfront resort on private 85 acres of land and offers free WiFi, full service spa, and guest rooms with water views. (updated Dec 2015)
• Hampton Inn & Suites Fort Myers-Estero/FGCU, 10611 Chevrolet Way (Estero), ☏ +1-239-947-5566. (updated Feb 2020)
• Luxury Vacation Rentals of Fort Myers, 276 CAROLINA AVE, FORT MYERS BEACH, FLORIDA, 33931, ☏ +1 239 281-6402, rentals@luxuryvacationrentalsfl.com. (updated Aug 2021)

While Fort Myers is mostly safe, there are a few scattered neighborhoods, especially east and southeast of downtown, where it is wise to use a bit of caution, especially at night. The most reliable method of identifying what portions of the area are least safe is to consult the Lee County Sheriff Department. They provide Web services that graphically depict all of the high crime areas. Visitors will find that opinions not supported by statistics from the Lee County Chamber of Commerce or, Lee County Sheriff Department may not be based in fact. The Lee County Sheriff Department web-site address is: http://www.sheriffleefl.org.